LRRK2 can function as a protein kinase and mutations lead to increased kinase activity. Mutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset, autosomal dominant familial Parkinson`s disease (PD) and variation at the LRRK2 locus contributes to the risk for idiopathic PD. 10 Max Planck Institute for Heart and Lung Research, Ludwigstr.9 Center for Molecular Medicine (CMMC), University of Cologne, Germany.8 Institute for Mitochondrial Diseases and Aging, Medical Faculty, University of Cologne, D-50931 Cologne, Germany.7 Université de Bourgogne Franche-Comté, UMR Centre des Sciences du Goût et de l'Alimentation, F-21000 Dijon, France.6 INRA, UMR1324 Centre des Sciences du Goût et de l'Alimentation, F-21000 Dijon, France.5 CNRS, UMR6265 Centre des Sciences du Goût et de l'Alimentation, F-21000 Dijon, France.4 Biochemistry II, Molecular Neurobiochemistry Faculty for Chemistry and Biochemistry Ruhr-University Bochum, NC 7/174 Universitaetsstraße 150, 44780 Bochum, Germany.3 Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, Michigan, USA.2 Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.
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